S. Korean experts advise caution on using AstraZeneca’s COVID-19 vaccine on older adults
The company is developing a vaccine with researchers from the University of Oxford
The COVID-19 vaccine, developed by scientists from Oxford and AstraZeneca, precisely follows the genetic instructions programmed by its developers to successfully induce a strong immune response, according to detailed analysis by independent British scientists..
"The vaccine does everything we expected and this is good news in our fight against the disease," said David Matthews, an expert in virology at the University of Bristol, who led the study..
AstraZeneca, which is developing a vaccine with researchers from Oxford University, is considered one of the leaders in the race to create a vaccine for COVID-19.
The first results of large-scale, late-stage clinical trials in several countries around the world, including Brazil, the United States and the United Kingdom, are expected to be published by the end of the year..
The vaccine, known as ChAdOx1 or AZD1222, is made by taking a chimpanzee adenovirus and removing about 20 percent of its instructions. This prevents the vaccine from replicating or causing disease in humans..
Researchers from Bristol focused on assessing how often and how accurately the vaccine copies and uses the genetic instructions programmed by the developers. These instructions detail how to get the spike protein from the SARS-CoV-2 coronavirus that causes COVID-19.
Once a spike protein has formed, the immune system responds by training the immune system to detect a true COVID-19 infection..
"This is an important study because we can confirm that the genetic instructions behind this vaccine … are correctly followed when they enter a human cell," said Matthews..
His group’s research has not yet been peer-reviewed, but has been published as a preprint prior to peer review..
The company said that this is a normal procedure that is used when a test participant develops a potentially unexplained illness. One of the coronavirus…
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